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Recent Publications
Tan, J.M.J., Garner, M.E., Regeimbal, J.M., Greene, C.J., Márquez, J.D.R., Ammendolia, D.A., McCluggage, A.R.R., Li, T., Wu, K.J., Cemma, M., Ostrowski, P.P., Raught, B., Diamond, M.S., Grinstein, S., Yates, R.M., Higgins, D.E., and Brumell, J.H. (2021) Listeria exploits IFITM3 to suppress antibacterial activity in phagocytes. Nat. Commun. 12(1):4999. PDF
Del Valle, A., Acosta-Rivero, N., Laborde, R.J., Cruz-Leal,Y., Cabezas, S., Luzardo, M.C., Alvarez, C., Labrada, M., Rodríguez, A., Rodríguez, G.L., Raymond, J,. Nogueira, C.V., Grubaugh, D., Fernández, L.E., Higgins, D., and Lanio, M.E. (2021) Sticholysin II shows similar immunostimulatory properties to LLO stimulating dendritic cells and MHC-I restricted T cell responses of heterologous antigen. Toxicon. (200):38-47.
Laborde, R.J., Ishimura, M.E., Abreu-Butin, L., Nogueira, C.V., Grubaugh, D., Cruz-Leal, Y., Luzardo, M.C., Fernández, A., Mesa, C., Pazos, F., Álvarez, C., Alonso, M.E., Starnbach, M.N., Higgins, D.E., Fernández, L.E., Longo-Maugéri, I.M., and Lanio, M.E. (2021) Sticholysins, pore-forming proteins from a marine anemone can induce maturation of dendritic cells through a TLR4 dependent-pathway. Mol. Immunol. (131):144-154. PDF
Rojas Márquez, J.D., Li, T., McCluggage, A.R.R, Tan, J.M.J, Muise, A., Higgins, D.E., and Brumell, J.H. (2021) Cutting Edge: NOX2 NADPH oxidase controls infection by an intracellular bacterial pathogen through limiting the type 1 IFN response. J. Immunol. 206(2):323-328. PDF
Ghosh, P., Zhou, Y., Richardson, Q., and Higgins, D.E. (2019) Characterization of the pathogenesis and immune response to Listeria monocytogenes strains isolated from a sustained national outbreak. Sci. Rep. 9(1):19587. PDF
Tan, J.M.J., Mellouk, N., Osborne, S.E., Ammendolia, D.A., Dyer, D.N., Li, R., Brunen, D., van Rijn, J.M., Huang, J., Czuczman, M.A., Cemma, M.A., Won, A.M., Yip, C.M., Xavier, R.J., MacDuff, D.A., Reggiori, F., Debnath, J., Yoshimori, T., Kim, P.K., Fairn, G.D., Coyaud, E., Raught, B., Muise, A.M., Higgins, D.E., and Brumell, J.H. (2018) An ATG16L1-dependent pathway promotes plasma membrane repair and limits Listeria monocytogenes cell-to-cell spread. Nat. Microbiol. (12):1472-1485. PDF
Cruz-Leal, Y., Grubaugh, D., Nogueira, C.V., Lopetegui-González, I., Del Valle, A., Escalona, F., Laborde, R.J., Alvarez, C., Fernández, L.E., Starnbach, M.N., Higgins, D.E., and Lanio, M.E. (2018) The vacuolar pathway in macrophages plays a major role in antigen cross-presentation induced by the pore-forming protein sticholysin II encapsulated into liposomes. Front. Immunol. 9:2473. PDF
Ghosh, P., and Higgins, D.E. (2018) Listeria monocytogenes infection of the brain. J. Vis. Exp. Oct. 2(140). PDF
Ghosh, P., Halvorsen, E.M., Ammendolia, D.A., Mor-Vaknin, N., O'Riordan, M.X.D., Brumell, J.H., Markovitz, D.M., and Higgins, D.E. (2018) Invasion of the brain by Listeria monocytogenes is mediated by InlF and host cell vimentin. MBio. 9(1): e00160-18. PDF
Grubaugh, D., Regeimbal, J.M., Ghosh, P., Zhou, Y., Lauer, P., Dubensky, T.W. Jr., and Higgins, D.E. (2018) The VirAB ABC transporter is required for VirR regulation of Listeria monocytogenes virulence and resistance to nisin. Infect. Immun. 86(3): e00901-17. PDF
Zhang, T., Abel, S., Abel Zur Wiesch, P., Sasabe, J., Davis, B.M., Higgins, D.E., and Waldor, M.K. (2017) Deciphering the landscape of host barriers to Listeria monocytogenes infection. Proc. Natl. Acad. Sci. U.S.A. 114(24):6334-6339. PDF
Laborde, R.J., Sanchez-Ferras, O., Luzardo, M.C., Cruz-Leal, Y., Fernández, A., Mesa, C., Oliver, L., Canet, L., Abreu-Butin, L., Nogueira, C.V., Tejuca, M., Pazos, F., Álvarez, C., Alonso, M.E., Longo-Maugéri, I.M., Starnbach, M.N., Higgins, D.E., Fernández, L.E., and Lanio, M.E. (2017) Novel adjuvant based on the pore-forming protein sticholysin II encapsulated into liposomes effectively enhances the antigen-specific CTL-mediated immune response. J. Immunol. 198(7):2772-2784. PDF
Osborne, S.E., Sit, B., Shaker, A., Currie, E., Tan, J.M., van Rijn, J., Higgins, D.E., and Brumell, J.H. (2017) Type I interferon promotes cell-to-cell spread of Listeria monocytogenes. Cell. Microbiol. Mar. 19(3). PDF
Picard, M.D., Bodmer, J., Gierahn, T.M., Lee, A., Price, J., Cohane, K., Clemens, V., DeVault, V.L., Gurok, G., Kohberger, R., Higgins, D.E., Siber, G.R., Flechtner, J.B., and Geisler. W.M. (2015) Resolution of Chlamydia trachomatis infection is associated with a distinct T cell response profile. Clin. Vaccine Immunol. 22(11): 1206–1218. PDF
Cemma, M., Lam, G.Y., Stöckli, M., Higgins, D.E., and Brumell, J.H. (2015) Strain-specific interactions of Listeria monocytogenes with the autophagy system in host cells. PLoS One. 10(5): e0125856. PDF
Fattouh, R., Kwon, H., Czuczman, M.A., Copeland, J.W., Pelletier, L., Quinlan, M.E., Muise, A.M., Higgins, D.E., and Brumell, J.H. (2015) The diaphanous-related formins promote protrusion formation and cell-to-cell spread of Listeria monocytogenes. J. Infect. Dis. 211(7): 1185–1195. PDF
Alonso, A.N., Perry, K.J., Regeimbal, J.M., Regan, P.M., and Higgins, D.E. (2014) Identification of Listeria monocytogenes determinants required for biofilm formation. PLoS One. 9(12): e113696. PDF
Czuczman, M.A., Fattouh, R., van Rijn, J.M., Canadien, V., Osborne, S., Muise, A.M., Kuchroo, V.K., Higgins, D.E., and Brumell, J.H. (2014) Listeria monocytogenes exploits efferocytosis to promote cell-to-cell spread. Nature. 509(7499): 230-234. PDF
Grubaugh, D., Flechtner, J.B., and Higgins, D.E. (2013) Proteins as T cell antigens: Methods for high-throughput identification. Vaccine. 31(37): 3805-3810. PDF
Perry, K.J., and Higgins, D.E. (2013) A differential fluorescence-based genetic screen identifies Listeria monocytogenes determinants required for intracellular replication. J. Bacteriol. 195(15): 3331-3340. PDF
Lam, G.Y., Cemma, M., Muise, A.M., Higgins, D.E., and Brumell, J.H. (2013) Host and bacterial factors that regulate LC3 recruitment to Listeria monocytogenes during the early stages of macrophage infection. Autophagy. 9(7): 985–995. PDF
Chen, L., Chen, Z., Baker, K., Halvorsen, E.M., da Cunha, A.P., Flak, M.B., Gerber, G., Huang, Y.H., Hosomi, S., Arthur, J.C., Dery, K.J., Nagaishi, T., Beauchemin, N., Holmes, K.V., Ho, J.W., Shively, J.E., Jobin, C., Onderdonk, A.B., Bry, L., Weiner, H.L., Higgins, D.E., and Blumberg, R.S. (2012) The short isoform of the CEACAM1 receptor in intestinal T cells regulates mucosal immunity and homeostasis via Tfh cell induction. Immunity. 37(5): 930-946. PDF
Picard, M.D., Cohane, K.P., Gierahn, T.M., Higgins D.E., and Flechtner, J.B. (2012) High-throughput proteomic screening identifies Chlamydia trachomatis antigens that are capable of eliciting T cell and antibody responses that provide protection against vaginal challenge. Vaccine. 30(29): 4387-4393. PDF
Lam, G.Y., Czuczman, M.A., Higgins, D.E., and Brumell, J.H. (2012) Interactions of Listeria monocytogenes with the autophagy system of host cells. Adv. Immunol. 113: 7-18. PDF
Lam, G.Y., Fattouh, R., Muise, A.M., Grinstein, S., Higgins, D.E., and Brumell, J.H. (2011) Listeriolysin O suppresses phospholipase C-mediated activation of the microbicidal NADPH oxidase to promote Listeria monocytogenes infection. Cell Host Microbe. 10(6): 627-634. PDF
Kamp, H.D., and Higgins, D.E. (2011) A protein thermometer controls temperature-dependent transcription of flagellar motility genes in Listeria monocytogenes.
PLoS Pathog. 7(8): e1002153. PDF
Moffitt, K.L., Gierahn, T.M., Lu, Y.J., Gouveia, P., Alderson, M.,
Flechtner, J.B., Higgins, D.E., and Malley, R. (2011) T(H)17-based
vaccine design for prevention of Streptococcus
pneumoniae colonization. Cell
Host Microbe 9(2): 158-165. PDF
Lieberman, L.A., and Higgins, D.E. (2010) Inhibition of Listeria monocytogenes infection by
neurological drugs. Int. J.
Antimicrob. Agents 35(3): 292-296. PDF
Kamp, H.D., and Higgins, D.E. (2009) Transcriptional and
post-transcriptional regulation of the GmaR antirepressor governs
temperature-dependent control of flagellar motility in Listeria monocytogenes. Mol. Microbiol. 74(2): 421-435. PDF
Burrack, L.S., Harper J.W., and Higgins, D.E. (2009) Perturbation of
vacuolar maturation promotes listeriolysin O-independent vacuolar
escape during Listeria monocytogenes
infection of human cells. Cell.
Microbiol. 11(9): 1382-1398. PDF
Shen, A., Higgins, D.E., and Panne, D. (2009) Recognition of AT-rich
DNA binding sites by the MogR repressor. Strucure 17(5): 769-777. PDF
Lieberman, L.A., and Higgins, D.E. (2009) A small-molecule screen
identifies the antipsychotic drug pimozide as an inhibitor of Listeria monocytogenes infection. Antimicrob. Agents Chemother.
53(2): 756-764. PDF
Kaser, A., Lee, A.H., Franke, A., Glickman, J.N., Zeissig, S., Tilg,
H., Nieuwenhuis, E.E., Higgins, D.E., Schreiber, S., Glimcher, L.H.,
and Blumberg, R.S. (2008) XBP1 links ER stress to intestinal
inflammation and confers genetic risk for human inflammatory bowel
disease. Cell 134(5):
743-756. PDF
Kirchner, M. and Higgins, D.E. (2008) Inhibition of ROCK activity
allows InlF-mediated invasion and increased virulence of Listeria monocytogenes. Mol. Microbiol. 68(3): 749-767. PDF
Smithey, M.J., Brandt, S., Freitag, N.E., Higgins, D.E., and Bouwer,
H.G. (2008) Stimulation of enhanced CD8 T cell responses following
immunization with a hyper-antigen secreting intracytosolic bacterial
pathogen. J. Immunol. 180(5):
3406-3416. PDF
Birmingham, C.L., Higgins, D.E., and Brumell, J.H. (2008) Avoiding
death by autophagy: interactions of Listeria
monocytogenes with the macrophage autophagy system. Autophagy. 4(3): 368-371. PDF
Birmingham, C.L., Canadien, V., Kaniuk, N.A., Steinberg, B.E., Higgins,
D.E., and Brumell, J.H. (2008) Listeriolysin O allows Listeria monocytogenes replication
in macrophage vacuoles. Nature.
451(7176): 350-354. PDF
Birmingham, C.L., Canadien, V., Gouin, E., Troy, E.B., Yoshimori, T.,
Cossart, P., Higgins, D.E., and Brumell, J.H. (2007) Listeria monocytogenes evades
killing by autophagy during colonization of host cells. Autophagy. 3(5): 442-451. PDF
Lemon, K.P., Higgins, D.E., and Kolter, R. (2007) Flagellar motility is
critical for Listeria monocytogenes
biofilm formation. J. Bacteriol.
189(12): 4418-4424. PDF
Burrack, L.S. and Higgins, D.E. (2007) Genomic approaches to
understanding bacterial virulence. Curr.
Opin. Microbiol. 10(1): 4-9. PDF
Alberti-Segui, C., Goeden, K.R. and Higgins, D.E. (2007) Differential
function of Listeria monocytogenes
listeriolysin O and phospholipases C in vacuolar dissolution following
cell-to-cell spread. Cell. Microbiol.
9(1): 179-195. PDF
Shen, A., Kamp, H.D., Gründling, A., and Higgins, D.E. (2006) A
bifunctional O-GlcNAc transferase governs flagellar motility through
anti-repression. Genes Dev.
20(23): 3283-3295. PDF
Roan, N.R., Gierahn, T.M., Higgins, D.E. and Starnbach, M.N. (2006)
Monitoring the T cell response to genital tract infection. Proc. Natl. Acad. Sci. U.S.A.
103(32): 12069-12074. PDF
Yoshida, M., Kobayashi, K., Kuo, T.T., Bry, L., Glickman, J.N.,
Claypool, S.M., Kaser, A., Nagaishi, T., Higgins, D.E., Mizoguchi, E.,
Wakatsuki, Y., Roopenian, D.C., Mizoguchi, A., Lencer, W.I. and
Blumberg, R.S. (2006) Neonatal Fc receptor for IgG regulates mucosal
immune responses to luminal bacteria. J.
Clin. Invest. 116(8): 2142-2151. PDF
Shen, A. and Higgins, D.E. (2006) The MogR transcriptional repressor
regulates nonhierarchal expression of flagellar motility genes and
virulence in Listeria monocytogenes.
PLoS Pathog. 2(4):
e30. PDF
Bouwer, H.G.A., Alberti-Segui, C., Montfort, M.J., Berkowitz, N.D., and
Higgins, D.E. (2006) Directed antigen delivery as a vaccine strategy
for an intracellular bacterial pathogen. Proc. Natl. Acad. Sci. U.S.A.
103(13): 5102-5107. PDF
Henry, R., Shaughnessy, L., Loessner, M.J., Alberti-Segui, C., Higgins,
D.E. and Swanson, J.A. (2006) Cytolysin-dependent delay of vacuole
maturation in macrophages infected with Listeria monocytogenes. Cell. Microbiol. 8(1): 107-119. PDF
Shen, A. and Higgins, D.E. (2005) The 5’ untranslated region-mediated
enhancement of
intracellular listeriolysin O production is required for Listeria monocytogenes
pathogenicity. Mol. Microbiol.
57(5): 1460-1473. PDF
Li, Z., Zhao, X., Higgins, D.E. and Frankel, F.R. (2005) Conditional
lethality yields a new vaccine strain of Listeria monocytogenes for
induction of cell-mediated immunity. Infect.
Immun. 73(8): 5065-5073. PDF
Agaisse, H., Burrack, L.S., Philips, J.A., Rubin, E.J., Perrimon, N.
and
Higgins, D.E. (2005) Genome-wide RNAi screen for host factors required
for intracellular bacterial infection. Science. 309(5738): 1248-1251. PDF
Pan, H., Yan, B., Rojas, M., Shebzukhov, Y.V., Zhou, H.,
Kobzik, L., Higgins, D.E., Daly, M., Bloom, B.R. and Kramnik, I.
(2005) Ipr1 gene mediates
innate immunity to tuberculosis. Nature.
434(7034): 767-772. PDF
Boyartchuk, V.,
Rojas, M., Yan, B., Jobe, O., Hurt, N.,
Dorfman, D.M., Higgins, D.E., Dietrich, W.F. and Kramnik, I. (2004) The
host resistance locus sst1
controls innate immunity to Listeria monocytogenes infection in immunodeficient mice. J.
Immunol. 173(8): 5112-5120. PDF
Gründling, A., Burrack, L.S., Bouwer, H.G.A.
and Higgins, D.E. (2004) Listeria monocytogenes regulates flagellar motility gene
expression through MogR, a transcriptional repressor required for
virulence. Proc. Natl. Acad. Sci. U.S.A. 101(33): 12318-12323. PDF
Starks, H., Bruhn, K.W., Shen, H., Barry, R.A.,
Dubensky, T.W., Brockstedt, D., Hinrichs, D.J., Higgins, D.E.,
Miller, J.F., Giedlin, M. and Bouwer, H.G.A.
(2004) Listeria monocytogenes
as a vaccine vector: virulence attenuation or existing antivector
immunity does not diminish therapeutic efficacy. J. Immunol. 173(1): 420-427. PDF
Hu, P.Q., Tuma-Warrino, R.J., Bryan, M.A., Mitchell,
K.G., Higgins, D.E., Watkins, S.C. and Salter, R.D. (2004) Escherichia
coli expressing recombinant
antigen and listeriolysin O stimulate class I-restricted CD8+
T cells following uptake by human APC. J. Immunol. 172(3): 1595-1601. PDF
Gründling, A., Gonzalez, M.D. and Higgins, D.E.
(2003) Requirement of the Listeria monocytogenes broad-range phospholipase PC-PLC during
infection of human epithelial cells. J. Bacteriol. 185(21): 6295-6307. PDF
Radford, K.J., Higgins, D.E., Pasquini, S., Cheadle,
E.J., Carta, L., Jackson, A.M., Lemoine, N.R. and Vassaux, G. (2002) A
recombinant E. coli to
promote MHC class I-dependent antigen presentation: application to
cancer immunotherapy. Gene Therapy 9(21): 1455-1463. PDF
Dancz, C.E., Haraga, A., Portnoy, D.A. and
Higgins, D.E. (2002) Inducible control of virulence gene expression in Listeria
monocytogenes: temporal
requirement of listeriolysin O during intracellular infection. J.
Bacteriol. 184(21): 5935-5945. PDF
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