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Department of Microbiology and
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Recent PublicationsShen, A., Higgins, D.E., and Panne, D. (2009) Recognition of AT-rich DNA binding sites by the MogR repressor. Strucure 17(5): 769-777. PDFLieberman, L.A., and Higgins, D.E. (2009) A small-molecule screen identifies the antipsychotic drug pimozide as an inhibitor of Listeria monocytogenes infection. Antimicrob. Agents Chemother. 53(2): 756-764. PDF Kaser, A., Lee, A.H., Franke, A., Glickman, J.N., Zeissig, S., Tilg, H., Nieuwenhuis, E.E., Higgins, D.E., Schreiber, S., Glimcher, L.H., and Blumberg, R.S. (2008) XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell 134(5): 743-756. PDF Kirchner, M. and Higgins, D.E. (2008) Inhibition of ROCK activity allows InlF-mediated invasion and increased virulence of Listeria monocytogenes. Mol. Microbiol. 68(3): 749-767. PDF Smithey, M.J., Brandt, S., Freitag, N.E., Higgins, D.E., and Bouwer, H.G. (2008) Stimulation of enhanced CD8 T cell responses following immunization with a hyper-antigen secreting intracytosolic bacterial pathogen. J. Immunol. 180(5): 3406-3416. PDF Birmingham, C.L., Higgins, D.E., and Brumell, J.H. (2008) Avoiding death by autophagy: interactions of Listeria monocytogenes with the macrophage autophagy system. Autophagy. 4(3): 368-371. PDF Birmingham, C.L., Canadien, V., Kaniuk, N.A., Steinberg, B.E., Higgins, D.E., and Brumell, J.H. (2008) Listeriolysin O allows Listeria monocytogenes replication in macrophage vacuoles. Nature. 451(7176): 350-354. PDF Birmingham, C.L., Canadien, V., Gouin, E., Troy, E.B., Yoshimori, T., Cossart, P., Higgins, D.E., and Brumell, J.H. (2007) Listeria monocytogenes evades killing by autophagy during colonization of host cells. Autophagy. 3(5): 442-451. PDF Lemon, K.P., Higgins, D.E., and Kolter, R. (2007) Flagellar motility is critical for Listeria monocytogenes biofilm formation. J. Bacteriol. 189(12): 4418-4424. PDF Burrack, L.S. and Higgins, D.E. (2007) Genomic approaches to understanding bacterial virulence. Curr. Opin. Microbiol. 10(1): 4-9. PDF Alberti-Segui, C., Goeden, K.R. and Higgins, D.E. (2007) Differential function of Listeria monocytogenes listeriolysin O and phospholipases C in vacuolar dissolution following cell-to-cell spread. Cell. Microbiol. 9(1): 179-195. PDF Shen, A., Kamp, H.D., Gründling, A., and Higgins, D.E. (2006) A bifunctional O-GlcNAc transferase governs flagellar motility through anti-repression. Genes Dev. 20(23): 3283-3295. PDF Roan, N.R., Gierahn, T.M., Higgins, D.E. and Starnbach, M.N. (2006) Monitoring the T cell response to genital tract infection. Proc. Natl. Acad. Sci. U.S.A. 103(32): 12069-12074. PDF Yoshida, M., Kobayashi, K., Kuo, T.T., Bry, L., Glickman, J.N., Claypool, S.M., Kaser, A., Nagaishi, T., Higgins, D.E., Mizoguchi, E., Wakatsuki, Y., Roopenian, D.C., Mizoguchi, A., Lencer, W.I. and Blumberg, R.S. (2006) Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria. J. Clin. Invest. 116(8): 2142-2151. PDF Shen, A. and Higgins, D.E. (2006) The MogR transcriptional repressor regulates nonhierarchal expression of flagellar motility genes and virulence in Listeria monocytogenes. PLoS Pathog. 2(4): e30. PDF Bouwer, H.G.A., Alberti-Segui, C., Montfort, M.J., Berkowitz, N.D., and Higgins, D.E. (2006) Directed antigen delivery as a vaccine strategy for an intracellular bacterial pathogen. Proc. Natl. Acad. Sci. U.S.A. 103(13): 5102-5107. PDF Henry, R., Shaughnessy, L., Loessner, M.J., Alberti-Segui, C., Higgins, D.E. and Swanson, J.A. (2006) Cytolysin-dependent delay of vacuole maturation in macrophages infected with Listeria monocytogenes. Cell. Microbiol. 8(1): 107-119. PDF Shen, A. and Higgins, D.E. (2005) The 5’ untranslated region-mediated enhancement of intracellular listeriolysin O production is required for Listeria monocytogenes pathogenicity. Mol. Microbiol. 57(5): 1460-1473. PDF Li, Z., Zhao, X., Higgins, D.E. and Frankel, F.R. (2005) Conditional lethality yields a new vaccine strain of Listeria monocytogenes for induction of cell-mediated immunity. Infect. Immun. 73(8): 5065-5073. PDF Agaisse, H., Burrack, L.S., Philips, J.A., Rubin, E.J., Perrimon, N. and Higgins, D.E. (2005) Genome-wide RNAi screen for host factors required for intracellular bacterial infection. Science. 309(5738): 1248-1251. PDF Pan, H., Yan, B., Rojas, M., Shebzukhov, Y.V., Zhou, H., Kobzik, L., Higgins, D.E., Daly, M., Bloom, B.R. and Kramnik, I. (2005) Ipr1 gene mediates innate immunity to tuberculosis. Nature. 434(7034): 767-772. PDF Boyartchuk, V., Rojas, M., Yan, B., Jobe, O., Hurt, N., Dorfman, D.M., Higgins, D.E., Dietrich, W.F. and Kramnik, I. (2004) The host resistance locus sst1 controls innate immunity to Listeria monocytogenes infection in immunodeficient mice. J. Immunol. 173(8): 5112-5120. PDF Gründling, A., Burrack, L.S., Bouwer, H.G.A. and Higgins, D.E. (2004) Listeria monocytogenes regulates flagellar motility gene expression through MogR, a transcriptional repressor required for virulence. Proc. Natl. Acad. Sci. U.S.A. 101(33): 12318-12323. PDF Starks, H., Bruhn, K.W., Shen, H., Barry, R.A., Dubensky, T.W., Brockstedt, D., Hinrichs, D.J., Higgins, D.E., Miller, J.F., Giedlin, M. and Bouwer, H.G.A. (2004) Listeria monocytogenes as a vaccine vector: virulence attenuation or existing antivector immunity does not diminish therapeutic efficacy. J. Immunol. 173(1): 420-427. PDF Hu, P.Q., Tuma-Warrino, R.J., Bryan, M.A., Mitchell,
K.G., Higgins, D.E., Watkins, S.C. and Salter, R.D. (2004) Escherichia
coli expressing recombinant
antigen and listeriolysin O stimulate class I-restricted CD8+
T cells following uptake by human APC. J. Immunol. 172(3): 1595-1601. PDF Radford, K.J., Higgins, D.E., Pasquini, S., Cheadle,
E.J., Carta, L., Jackson, A.M., Lemoine, N.R. and Vassaux, G. (2002) A
recombinant E. coli to
promote MHC class I-dependent antigen presentation: application to
cancer immunotherapy. Gene Therapy 9(21): 1455-1463. PDF
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